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A trial with eye drops of practolol, 0.2% and propranolol, 0.1%, and intravenous injection of practolol, 1-4mg/kg. and propranolol, 0.5-2mg/kg. in rabbits was done for the changes of ocular tension. Ocular tension was estimated by Scheitz tonometer. The E.C.G. was recorded before and after treatment of the above drugs. In the rabbits all of doses of practolol, topically and systemically applied failed to reduce ocular tension, but propranolol reduced slightly ocular tension which was suggested. that the lowering of ocular tension was mediated by its local anesthetic activity.
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